Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF METFORMIN HYDROCHLORIDE

*Chetan M. Jadhav, Bharat W. Tekade, Vinod M. Thakare, Vijay R. Patil

Department Of Pharmaceutices, T.V.E.S’s Hon’ble Loksevak Madhukarrao Chudhari College of Pharmacy, Faizpur, Jalgaon, MH.

ABSTRACT

The objective of the study was to develop matrix tablets of Metformin hydrochloride for Sustained Release. Hydroxy Propyl Methyl Cellulose (HPMC) K15M and Xanthan Gum as the retardant polymers and study the effect of various formulation factors such as polymer proportion, polymer type and effect of filler type on the in vitro release of the drug. Matrix tablets were prepared by wet granulation method and prepared tablets were evaluated for weight variation, friability, hardness, thickness and in vitro dissolution studies. All granules of formulations showed compliance with pharmacopoeial standards. In vitro release studies shows that the formulation containing lower concentration of polymer had earlier drug release. As concentration of polymer increased, drug release was found to be retarded. The formulations F6 sustained release of drug for 12 hrs with 98.28%. Because of swelling property increased the drug release profile to a small extent due to change in swelling at the tablet surface. The kinetic treatment showed that the mechanism of drug tablets of Metformin hydrochloride up to 12 hrs can overcome the disadvantages of conventional tablets.

Keywords: Metformin hydrochloride, HPMC K15M, Xanthan Gum, Sustained release, Matrix tablet.