Abstract

ANTIMICROBIAL SCREENING OF NOVEL 4-HYDROXY CHALCONES

Bushra Ahmed Kateb*, Abdulkareem Ali Hussien, Heena Mirza Baig, M. A. Baseer and P. A. Kulkarni

ABSTRACT

In a wide search program toward new antimicrobial agents, a series of Chalcones (4a-j) have been synthesized by Claisen-Schmidt condensation of 4-hydroxy-3,5di iodo acetophenone with several aromatic aldehydes in presence of aqueous solution of potassium hydroxide at room temperature. The synthesized chalcones were characterized by Physical and spectral methods such as melting point, IR, 1H-NMR and Mass analysis. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr –ve Bacillus subtilis gr +ve, Salmonella typhi gr –ve and antifungal activity against Aspergillus oryzoe, Aspergillus niger,. DMSO was used as solvent control for their antimicrobial activity using disc diffusion method. Synthesis and biological evaluation of chalcone derivatives have been a topic of special interest to organic and medicinal chemists. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.

Keywords: 4-Hydroxy Chalcones, Antibacterial activity, Antifungal activity.