Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Ravindra B. Kumbhar, Pramod J. Shirote, Dhanashree S. Chavan, Sachin A. Pishawikar*, Harinath N. More, Suresh G. Killedar

ABSTRACT

Drug absorption form gastrointestinal tract is a complex procedure and is subject to many variables. The extent of drug absorbed from gastrointestinal tract is related to its contact time. The real challenge in the development of an oral controlled release drug delivery system is, not only to sustain the drug release but also to prolong the presence of dosage form within gastrointestinal tract. This will help the entire drug to get completely released in desired time at the desired site leading to maximum absorption and increased bioavailability. Gastroretentive systems such as mucoadhesive, high-density, expandable and floating systems have been developed for drug that have better absorption form GIT but show reduced bioavailability due to lesser contact time. These systems provide controlled drug delivery with prolonged gastric residence time.

Keywords: Gastroretantive, MMC, low density, Bioadhesive Systems, floating drug delivery system.