Abstract

EVALUATION OF HYPOGLYCEMIC ACTIVITY OF METHANOLIC LEAF EXTRACT OF BRYONIA LACINIOSA IN ALLOXAN INDUCED DIABETIC RATS

Dr. Annem Srinivas Reddy* and Dr. Sneha Rajendran

ABSTRACT

The present study was aimed to evaluate the hypoglycemic activity of methanolic leaf extract of Bryonia laciniosa in alloxan induced diabetic rats. Albino rats of either sex were used for the study. The albino rats used for the experimental work were administered with alloxan (150 mg/kg) to induce diabetics. The rats having blood glucose levels above 200 mg/dl were selected and considered as diabetic rats. The diabetic rats were segregated Into groups, with a minimum of at least 6 in each group and treated with glibenclamide (5mg/kg), methanolic leaf extract of low dose 200 mg/kg and high dose 400 mg/kg separately for 14 days. Body weight measurements and blood glucose level estimations were recorded on the 1st day and 14th day of the experiment. Blood glucose levels are estimated with the glucometer. Blood glucose levels increased in alloxan induced diabetic rats but the methanolic leaf extract of B. laciniosa significantly reduced blood glucose levels. Body weight decreased in alloxan induced diabetic rats but an increase in body weight was seen in diabetic rats treated with glibenclamide, low and high dose of plant leaf extract.

Keywords: Alloxan, Bryonia laciniosa methanolic extract (BLME), Carboxy methyl cellulose (CMC), Hypoglycemic activity, Bodyweight, Glibenclamide.