Abstract

THE EFFECT OF THE ETHANOLIC EXTRACT OF OCYPODE PLATYTARSIS ON PARACETAMOL INDUCED LIVER DAMAGE IN RATS

I.Rajalakshmy* and V. Venkata gangadhar

ABSTRACT

Background: Throughout world marine organisms were used to treat many diseases. Aims: To study the hepatoprotective potential of Ocypode platytarsis crab extract against paracetamol induced liver damage. Methods: Hepatotoxicity was induced by administration of paracetamol (3g/kg) orally on the 7th day. The extract of Ocypode platytarsis was administrated at a dose of 400 mg/kg and 200 mg/kg for 7 consecutive days. In order to evaluate the effect of hepatoprotective activity of Ocypode platytarsis extract the serum enzymes serum glutamate oxaloacetate transaminase, Serum glutamate pyruvic transaminase, Alkaline Phosphate, Bilirubin, and Total protein were determined. Results: The Ocypode platytarsis extract shows a significant and dose dependent decrease in elevated serum enzymes of serum glutamate oxaloacetate transaminase, Serum glutamate pyruvic transaminase, Alkaline Phosphate, Bilirubin, and increase the Total protein levels, which is compared with paracetamol alone treated rats. Histopathological studies also showed the significant improvement in Ocypode platytarsis extract. Conclusion: The results of the present study reveal the hepatoprotective activity of Ocypode platytarsis against paracetamol induced liver damage in rats.

Keywords: Paracetamol, Ocypode platytarsis, hepatoprotective, silymarin, SGOT, SGPT, TOTAL PROTEIN, ALP, BILIRUBIN, rats.