Abstract

SODIUM ALGINATE CURCUMIN FLOATING BEADS CONTAINING CURCUMIN SOLID DISPERSION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.

Jitendra D. More, Monika Kamble and Chhaya H. Gadgoli*

ABSTRACT

Curcumin is a major component of rhizomes of Curcuma longa and has array of pharmacological activities. Poor bioavailability of the molecule is due to its poor solubility in water. In the present study, an attempt is made to increase the water solubility through preparation of solid dispersion (SD) of curcumin and Gelucire®44/14, followed by incorporation of the same in Sodium alginate floating beads (SCFB). The formation of SD was confirmed through FT-IR and DSC –TG analysis. The maximum entrapment of curcumin in the beads was found to be 30 % w/w. The dissolution studies of the beads in 0.1N HCl, revealed that the curcumin release from the beads containing SD is significantly (p<0.001) higher than the beads containing plain curcumin. Pharmacokinetic studies on beads containing SD of curcumin indicated significantly (P< 0.001) higher levels of curcumin serum as compared to the plain curcumin.

Keywords: Curcumin, Solid dispersion, Sodium Alginate Curcumin Floating beads, Bioavailabilitiy, Gelucire 44/14.