Abstract

NUCLEAR FACTOR-KAPPA-B – AS MOLECULAR TARGET IN ASTHMA

Dr. Navneet Om Prakash Soni*

ABSTRACT

Transcription factors (for example NF-κB, AP-1, GATA-3, STAT-1 STAT-6, c-Maf, NFATs and SOCS) have been implicated in the differentiation of Th2 lymphocytes and therefore represent therapeutic targets for asthma. The increased expression of these proteins seen in asthma is the result of enhanced gene transcription since many of the genes are not expressed in normal cells but are induced in a cell-specific manner during the inflammatory process. Changes in gene transcription are regulated by transcription factors, which are proteins that bind to DNA and modulate the transcriptional machinary. There are cell specific transcription factors that may be targeted for inhibition by peptide, ATP analogs, kinases, which could provide selectivity of drug action. The article highlight the History, Structure, Role, Function and importance of targeting NF-B.

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