ALTERATION IN BILE COMPOSITION AND FLOW RATE FOLLOWING MORINGA OLEIFERA LAM LEAF EXTRACT ADMINISTRATION IN SALT LOADED RATS
C. O. Nku, A. N. Archibong, *O. E. Ofem and E. J. Ani
ABSTRACT
Moringa oleifera Lam is an ethnopharmacological plant with huge
medicinal potentials. This study aimed to investigate the effect of leaf
extract of Moringa oleifera Lam on bile composition and flow rate in
salt loaded rats. 24 albino Wister rats were assigned into four groups of
six rats each and were given either normal rat feed and drinking water,
high salt diet (8% NaCl diet) + 1% NaCl drinking water and/or M.
oleifera Lam extract (600mg/kg b.w., orally, once daily). The feeding
regimens lasted six weeks. After an overnight fast, bile was collected
and analyzed. Both the salt fed and extract treated groups produced
significant increases in bile flow rate (p<0.001), biliary cholesterol
(p<0.001, p<0.05), and bilirubin (p<0.001) concentration compared
with the control group. This was followed by increase in biliary Na
(P<.001), cl (P<.001) and K (P<.001) concentration compared with the
control respectively. In conclusion consumption of Moringa oleifera leaf extract is essential
to health, even in high salt loaded rats, because it promote the liver and thereby enhance the
excretion of substances that may proof harmful to health.
Keywords: Bile, Moringa oleifera, cholesterol and Bilirubin.
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