Abstract

SYNTHESIS AND EVALUATION OF ACRYLIC MONOMERS BASED N. N’-METHYLENE BISACRYLAMIDE CROSSLINKED MUCOADHESIVE COPOLYMER HYDROGEL AS A CARRIER FOR CONTROLLED DRUG DELIVERY

Kaliappa Subramanian*, Chinnadurai Abarna, Sridhar Svetha and S. Abirami

ABSTRACT

Oral administration is the major route for drug delivery due to its simplicity and patient compliance. Peptides and proteins have become the drugs of choice for treating numerous diseases due to their incredible selectivity and ability to provide effective and potent action. But bioavailability of many hydrophobic drugs and protein/peptide drugs taken orally were very less due to their poor retention in gastro intestine (GI). The absorption of these drugs at GI tract can be enhanced significantly using mucoadhesive hydrogel polymers as drug carriers. In the present study mucoadhesive polymer hydrogels with different compositions were synthesised using the hydrophilic monomers such as hydroxyethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate and 2-acrylamido-2-methylpropane sulphonic acid and itaconic acid with methylene bisacrylanide as crosslinker and characterized. The polymers were thermaly stable, swellable in biofluids, biocompatible and adhered on goat intestine mucus much better than carboxymethyl cellulose sodium a mucoadhesive natural polymer. The mucoadhesion measured in the shear mode was found to vary with hydrogel composition. Invitro 5-fluorouracil release studies in simulated gastric and intestine fluids (SGF and SIF) revealed that the composition of the polymer and pH of the biofluid influenced the drug release kinetics. The observed results revealed that the synthesised mucoadhesive polymer hydrogel could serve as a promising carrier for controlled delivery of potent drugs at GI with the intended release rates.

Keywords: Polymer hydrogel, mucoadhesive, biofluids, cell viability, invitro drug release, gastro intestine