Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NEW OF NOVEL 1,3,4-OXADIAZOLE BEARNING THIOPHEN-2-CARBOXYLIC ACID

Sunder Kumar Kolli*

ABSTRACT

Oxadiazole compounds are various active pharma ingredients which exhibit different potent biological activities including antibacterial, antifungal and anticancer activities. Now our research concentrates the synthesis of different oxadiazole derivatives. Different carboxylic acid derivatives treated with ethanol in the presence of Conc.acids to give the intermediates then further its react with hydrazine hydrate followed by various carboxylic acida in the presence of POCl3 to give oxadiazole derivatives. All the newly synthesized compounds were synthesized compounds were screened for their antibacterial and antifungal studies.

Keywords: Thiophehe-2-Carboxylic acid, POCl3, antibacterial, antifungal activity and 2,5- disubstituted-1,3,4-oxadiazoles.