Abstract

POTENTIAL ROLE OF NANOTECHNOLOGY FOR SKIN DRUG DELIVERY

Kamal K.*, Garg D., Harikumar S.L. and Aggarwal G.

ABSTRACT

The field of drug development experiences very low success rates with regards to drugs that enter the market. This occurs due to factors such as toxicity of the therapeutic compounds, poor solubility leading to lowered bioavailability and thus reduced efficacy. Mainly it occur problems in transdermal delivery of drugs. Various approaches have been explored to address these challenges with little success. Nanotechnology is also a way to improve these problems. With the emergence of Nanotechnology, there has been remarkable improvement in the field of drug delivery system over the past decade. Nanotechnology in drug delivery system is an upcoming field and significant research has been conducted in this regard. It has been able to overcome some limitations encountered with the traditional routine drug delivery systems and hence emerged as an effective alternative. Nanotechnology contains nanomaterial having size range usually below 100 nm. The physicochemical properties of nanomaterial such as their small size, large surface area, surface charge and ability to functionalize them makes them potential delivery systems for effective therapies. Nanotechnology also improves the transdermal delivery of BCS class II & IV drugs. Many of the current “nano” drug delivery systems, however, are remnants of conventional drug delivery systems that happen to be in the nanometer range, such as liposomes, niosomes, transferosoems, nanoparticles and dendrimers. Nanotechnology is also opening up new opportunities in transdermal drug delivery system. This article reviews nanotechnology based different types of drug delivery systems for transdermal delivery.

Keywords: Nanotechnology, Nanomaterial, Nanocarriers etc.