Abstract

DIFFERENT APPROACHES TO CONTROL ANIMAL EXPERIMENT

Vaya Raj Kumar*, Jain Saloni, Vaya Rajesh and Garg Ayush

ABSTRACT

The origins of the concept of alternatives to animal testing in the 1950s and the range of replacement alternative methods and progress toward their incorporation into fundamental and applied research, education are discussed. The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern of ethics, there are few more disadvantages of animal high cost. Various alternatives to animal testing were proposed to overcome the experimentation like requirement of skilled manpower, time consuming protocols and drawbacks associated with animal experiments and avoid the unethical procedures. Different methods and alternative organisms are applied to implement this strategy. These methods provide an alternative means for the drug and chemical testing, up to some levels. A brief account of these alternatives and advantages associated is discussed in this review. An integrated application of these approaches would give an insight into minimum use of animals in scientific experiments.

Keywords: Alternatives, Refinement, In-vitro, In-silico, Animal ethics, Alternative organism, Laboratory animal etc.