Abstract

FORMULATION AND EVALUATION OF ORNIDAZOLE MATRIX TABLETS FOR COLON SPECIFIC DRUG DELIVERY

B. Manjula*, V. Aishwarya, Vinod Beulah, Y. Sudheer Kumar, A. Bharathi and Ch. Ashok

ABSTRACT

The basic aim of the present investigation is to formulate and evaluate colon specific tablets of ornidazole tablets were successfully prepared using enteric coated polymers eudragit, guar gum and hpmc k15m. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between ornidazole and excipients used in the formulation. Invitro release profiles of optimized form of F7 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. In vitro release profiles of optimized formulation of ornidazole controlled release tablets (F-7) were found to be improvised and followed zero - order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.

Keywords: study of the preformulation charcteristics, ornidazole, Invitro, showed ornidazole.