Abstract

SYNTHESIS AND EVALUATION OF ANTICANCEROUS ACTIVITY OF NOVEL 3, 4-DIARYLOXAZOL-2(3H)-ONES

*Nitin Dwivedi, Amit Khanna

People’s Institute of Pharmacy and Research Centre, People’s University Bhanpur, Bhopal (M.P.) 462037 India.

ABSTRACT

A series of 3, 4-diaryloxazol-2(3H)-ones are synthesize and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds, which have trimethoxy group near the oxazole ring the overall biological activity studies of the compounds in two series indicated that the compounds with the B-ring possessing 3,4,5- trimethoxy systems and the A-ring with a 4-methoxy substitution were more potent than their isomers with an interchange of the substitution pattern of rings A and B thus the compounds 18 and19 showed potential anticancer activity against human CEM cells with IC50 values of 0.15 and 0.25 lM, respectively.

Keywords: 3, 4-diaryloxazol-2(3H)-ones, Combrestatin A4, Oxazol, CEM Cells.