Abstract

FAST DISSOLVING DRUG DELIVERY SYSTEMS

Garg Deepak*, Aggarwal Geeta and Harikumar S.L.

ABSTRACT

Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. The conventional drug delivery system is mostly used for delivery of drugs. But these have prolonged onset of action due to slow disintegration and poor dissolution. To overcome these problems different novel drug delivery systems would introduced. The fast dissolving drug delivery system (FDDDS) is rapidly gaining interest in pharmaceutical Industry. Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to conventional tablet, capsule and syrups. These are used in the form of fast dissolving tablet (FDTs) and fast dissolving oral films (FDOFs). These disintegrate and dissolve within a minute, without needing water or chewing and enhance the potential for improved compliance in paediatrics and geriatric patients, who have difficulty in swallowing tablets or liquids. As fast dissolving tablet provide instantaneous disintegration after putting it on tongue, thereby rapid drug absorption and instant bioavailability, whereas fast dissolving oral films are used as practical alternative to fast dissolving tablets. In spite of the downside i.e., lack of immediate onset of action; these oral dosage forms have beneficial purposes such as self medication, increased compliance, ease of manufacturing and lack of pain. Hence fast dissolving tablet technology has been gaining significance now-a-days with wide variety of drugs serving many purposes. Fast dissolving tablets has ever increased their demand in the last decade since they disintegrate and dissolve in saliva in less than 60 seconds. FDDS are a proven and accepted technology for the systemic delivery of APIs for over-the-counter (OTC) medications.

Keywords: Fast Dissolving Drug delivery systems, Fast dissolving tablets, Oral films, API.