Abstract

TOXICOGENOMICS AND ITS APPLICATIONS

Dr. Sanjay B. Nandedkar and Dr. Yadunath C. Waykole

ABSTRACT

Toxicogenomics is a new scientific discipline describing the combination of a systematic and comprehensive study of gene expression in response to a nutrient/drug interaction in a biological system. High expectations are set on this new discipline to fundamentally change the process of drug development, especially in toxicity assessment. The use of expression profiling technologies to mechanistic and predictive toxicology, and biomarker discovery, will enable us to ask detailed questions and generate hypotheses. Ideally, such toxicology research will improve the quality of drug candidates and reduce the overall costs due to attrition during drug development. The integration of data from different toxicogenomic technologies has been explored to some extent but these approaches need to be integrated fully.

Keywords: Toxicogenomics, genomics, toxicology.