Abstract

EVALUATION AND COMPARISON BETWEEN LOCALLY AND SYSTEMICALLY ADMINISTERED NSAIDs USED IN GINGIVITIS AND PERIODONTITIS

Faiza Hasan* and Rahila Najam

ABSTRACT

The aim of the study was to develop an NSAID gel which was applied topically into the periodontal pockets along with the conventional treatment to improve the clinical variables as well as minimize the adverse effects associated with the systemic use of the NSAIDs. A total of 30 subjects were included in the study. The patients of gingivitis and periodontitis were recruited from Crown Dental Clinic, Karachi, Pakistan (private practice) between the periods of February 2015 to October 2015. 1% Aspirin gel was prepared and their physicochemical properties were also evaluated before the application in to the periodontal pockets.The results were compared statistically to its control using Student’s T test. The results were also compared using ANOVA followed by multiple comparisons with Dunnet’s T test and Bonferroni’s test. There is a statistically significant difference in the clinical variables between untreated and treated 1% ASA gel groups from baseline and 30 days after treatment (p<0.05). Thus, this research support the local use of NSAIDs to avoid the adverse effects associated with its systemic use.

Keywords: Aspirin, gel, gingivitis, periodontitis.