Abstract

NANOCARRIERS FOR TREATMENT OF DEEP FUNGAL INFECTIONS THROUGH TOPICAL GEL FORMULATION

Gajanan S. Sanap* and Guru Prasad Mohanta

ABSTRACT

Nanocarriers are highly interesting delivery systems for the dermal application of drugs. Based on a eudermic alkylpolyglycosid nanoemulsions, solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC) were prepared by hot homogenization technique. The aim of the investigation is to develop solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) as carriers for topical delivery of Miconazole nitrate (MN). They were characterized for particle size, zeta potential, entrapment efficiency and in vitro release profiles. Also the percutaneous permeation of MNSLN and MNNLC were investigated in abdominal rat skin using modified Franz diffusion cells. The particle size parameters and the surface electrical charge (ZP) have been evaluated immediately after production of the systems, and during one month of storage at three different temperatures 4ºC, 25ºC and 40ºC. The particles remained in their colloidal state during 1 months of storage at 4ºC, 20ºC and 40ºC. For all tested formulations the entrapment efficiency was higher than 90%. Differential scanning calorimetry (DSC) studies were performed to characterize the physicochemical properties of the SLN and NLC. High amount of MN release was facilitated through abdominal skin of rats from MN SLN than MN-NLC. Research work could be concluded as successful development of MN-loaded NLC to increase the encapsulation efficiency of colloidal lipid carriers with advantage of improved performance in terms of stability and provides a sustaining MN topical effect as well as faster relief from fungal infection.

Keywords: Miconazole nitrate; Nanostructured lipid carriers (NLC); Topical gels; Topical delivery.