Abstract

FORMULATION AND DEVELOPMENT OF BILAYER TABLETS OF CIMETIDINE AND PRAZIQUANTEL FOR TARGETED DELIVERY

Dr. Biswajit Basu* and Birju Bagthalia

ABSTRACT

In the present investigation bilayer tablets of cimetidine and praziquantel were prepared. Cimetidine is anhistamine H2 antagonist having synergistic effect with praziquantel and therefore it increases the therapeutic efficiency of the praziquantel. Cimetidine mainly locally acts on the stomach while praziquantel was targeted to the colon for. So in the present study first layer of cimetidine float and second layer of praziquantel was enteric coated. Individual optimization was carried out for both the layer. For the floating layer different swelling polymers like HPMC K4 M, HPMC K15 M and HPMC E3 LV were used with different concentration (10, 20 and 30%). After the polymer optimization concentration of sodium bicarbonate was optimized. Experimental design (CCD) was applied for the floating layer optimization. For the enteric coating layer optimization was carried out for different enteric coating polymers like Eudragit L100, Eudragit S100 and different method of granulation like Intragranulation, Ladling. Final formulation for both the layer was used for the final formulation of bilayer tablets. Different pre compression and post compression parameters were used for the evaluation of the bilayer tablet. The bilayer tablets were evaluated for in vitro drug release and both the layer were remained in the GIT for more than 12 hrs. Final bilayer tablets were putted for stability study at the interval of 15, 21 and 30 days. The data of stability showed no any significant difference with the before data of the tablets.

Keywords: Cimetidine, Floating layer, CCD, Praziquantel, Enteric coating layer, Bilayer tablets, Schistosomiasis.