Abstract

THE CHEMISTRY AND PHARMACOLOGICAL POTENTIAL OF 2- AZETIDINONES INCORPORATED WITH HALOGEN ATOMS AND CYANO GROUPS: A REVIEW

*Pradeep K. Soni, Chandrakant P. Shinde and Dr. Anand K. Halve

ABSTRACT

2-Azetidinones nitrogen containing four-membered heterocyclics with a unique ring system present in living organisms, natural products, drugs and in many other substances represent interesting chemistry and great biological potential and are useful to mankind and society in all walks of life. Besides antibiotic activity, the ring system exhibits a wide range of pharmacological activities which is attracting the attention of researchers. In recent years, renewed interest has been focused on the synthesis and modification of β-lactam ring to obtain new compounds by applying known or new methods for diverse pharmacological activities. The present review gives a brief account on the chemistry, reactivity and methods of synthesis focusing on the detailed and extensive update on biological and pharmacological profiles of azetidin-2-ones specially incorporated with halogen and cyano groups.

Keywords: ?-Lactam ring, 2-azetidinones, pharmacological activity, cyanoethylation, halogen and cyano groups.