Abstract

IN VITRO STUDIES ON BUCCOADHESIVE TABLETS OF METOCLOPRAMIDE

Jaydeep B. Pawar*, Somashekar Shyale and Vijayalakshmi Prakya

ABSTRACT

In this investigation an effort was made to develop buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing frequency. Buccoadhesive tablets of Metoclopramide (MCP) were prepared by direct compression method. The buccoadhesive tablets were evaluated for hardness, friability, drug content, surface pH, in-vitro mucoadhesion study and in-vitro drug release study. The physical characteristics, mucoadhesive strength and in-vitro drug release of formulated tablets were shown to be dependent on characteristics and composition of materials used. The surface pH of all tablets was found to be satisfactory, close to buccal pH. The mucoadhesive strength was increased by increasing polymer content. Formulations containing Carbopol 934P and HPMC K4M showed good bioadhesive strength. In order to ascertain the mode of release, the data was subjected to various release kinetic model. All the formulations followed Fickian release mechanism following Higuchi model.

Keywords: Metoclopramide, HPMC-K4M, Xanthan Gum, Na CMC, Mucoadhesive Strength.