Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL INVESTIGATIONS OF Ni(II) COMPLEXES WITH MIXED AZINES

Virendra Singh Shekhawat, Sarita Varshney and A. K. Varshney*

ABSTRACT

A new series of Ni(II) complexes were synthesized by the reaction of Nickel(II) acetate with new Schiff base ligands in 1:2 molar ratio using methanol as a reaction medium. Mixed azines used in these studies have been prepared by the condensation of hydrazine hydrate and suitable carbonyls in ethanol. The prepared complexes were isolated as solid products and characterized by elemental analysis and spectral studies. On the basis of spectral studies, a six coordinate distorted octahedral geometry for all of these complexes have been assigned. The biological activities of Schiff base ligands and their metal complexes with different concentration have been screened invitro
against some bacterial and fungal strain to assess their growth inhibitory potency. The metal complexes were shown to Possess more antibacterial and antifungal activities than the free mixed azine ligands.

Keywords: Nickel(II) complexes, Mixed azines, Antibacterial and Antifungal activities, Spectral studies.