Abstract

IN VITRO ANTI-PLATELET AGGREGATION ACTIVITY OF A CLASSICAL HRIDYA (CARDIOPROTECTIVE) YOGA OF BHAVAMISRA

Vidhya Unnikrishnan*, K. Nishteswar, B. R. Patel, Mukesh Nariya

ABSTRACT

Cardioprotection includes all mechanisms and means that contribute to the protection of the heart by reducing or even preventing myocardial damage. Antiplatelet drugs reduce the incidence of cardiovascular events by about 20-25% in people with established cardiovascular diseases or at high risk of cardiovascular diseases. In the present experiment, the impact of three different concentrations (i.e.10mg/ml, 5mg/ml and 2.5mg/ml) of Hridya yoga [formulation consisting of seven drugs namely Haritaki (Terminalia chebula Retz.),Vacha (Acorus calamus Linn.), Rasna (Alpinia galanga (L.) Willd.), Pippali (Piper longum Linn.), Sunthi (Zingiber officinale Roscoe), Shati (Hedychium spicatum Sm. in A.Rees.) and Pushkaramoola (Inula racemosa Hook.f.)] methanolic extract has been assessed on inhibition of platelet aggregation in Rat blood. The study was conducted using Platelet Aggregometer (turbidimetric method), in platelet rich plasma in response to Adenosine Diphosphate .The results obtained indicate that all the concentrations of hridya yoga extract showed effective antiplatelet aggregation activity and the maximum activity was observed at 10mg/ml concentration.

Keywords: Antiplatelet, Hridyayoga, Cardioprotection.