Abstract

EFFECT OF SURFACTANT ON SKIN PERMEATION STUDY OF PRONIOSOMAL GEL

Natarajan R*., Vithu.V.C., Abirami.M., Sabareesh.M. and Ananda Thangadurai. S

ABSTRACT

The transdermal proniosomal Gel for Enalapril maleate was prepared for the treatment of hypertension that is capable of efficiently delivering entrapped drug over an extended period of time. The physical mixture of Drug, lecithin, and cholesterol were subjected to compatibility study using FTIR absorption spectra. The fabricated transdermal gels were subjected to various evaluation parameters like, Determination of pH and viscosity, Vesicle size analysis, Rate of spontaneity, Encapsulation efficiency, In vitro skin permeation studies, Skin irritation test, and Stability studies. The in vitro skin permeation studies showed the cumulative permeation of 78.53±0.25%, 85.24±0.25%, 73.37±0.25%, and 82.58± 0.25% through the skin in 24 hours for the formulations GF1, GF2, GF3, and GF4 respectively. All the formulations from GF1 to GF4 showed zero order drug permeation with diffusion, non-fickian release as the possible mechanisms of drug release.

Keywords: Proniosomes, Transdermal gel, Lecithin, Cholesterol, Permeation studies, Surfactant.