Abstract

CUBIC LIQUID NANOCRYSTAL SYSTEM FOR DRUG DELIVERY: A STATE OF THE ART

Mohd. Zubair Ali*, Musarrat Husain Warsi, Abdul Muheem, Mohammed A Jahangir, Nayyar Parvez and Pramod K Sharma

ABSTRACT

The present review deals with the Cubic liquid nanocrystal systems, in which the submicron-sized particles envelope a unique well-defined self-assembled nanostructured aqueous dispersions. Now a days such systems (reversed bicontinuous cubic and hexagonal mesophases) are attracting more attention to the formulation scientists owing to their unique structures and physicochemical properties. Various therapeutically active molecules can be solubilized in either aqueous or oil phase and be protected from enzymatic degradation, hydrolysis and oxidation. Furthermore, several researchers have proved the sustained type of release behaviour of the bioactive from the lyotropic liquid crystal systems. In this article, an outline of current advancement and status of cubic liquid nanocrystal systems, with respect to their types, fabrication methods and applications in the field of drug delivery are presented. In addition to these, the commercial potential of this system is also summarized.

Keywords: Cubic liquid nanocrystal, Sustained release, Bioavailability, Applications