Abstract

MICROPSHERES AS A MULTIPARTICULATE DRUG DELIVERY SYSTEM: A REVIEW

Siraj Shaikh*, G. J. Khan, Shaikh Salman, Fakir Heena and Shaikh Shaoor, Shaikh Mohsin F.

ABSTRACT

For the treatment or diagnosis or mitigation of every disease or disorder there is need of the drug. The drug is delivered by various drug delivery systems. Various drugs having the problems of low solubility, high potency and poor stability. It creates the need to design more safer and effective drug delivery systems. The microspheres are one of the most promising multiparticulates drug delivery system which offers numerous applications including targeting site with specificity, maintain concentration at site of interest without untoward effects, controlled release of drug, improve efficacy, reduced toxicity, improve patient compliance and physicochemically stable.They are spherical and characteristically free flowing powder having particle size between 1-1000 μm.Microspheres are administered by filling in hard gelatin capsule.In future bycombining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials.The purpose of this review is to highlights various types of microspheres, different methods to preparation, applications and their evaluation parameters.

Keywords: Microspheres, controlled release, drug delivery system, low solubility.