COMPARATIVE ANALYSIS OF HEPATOPROTECTIVE EFFECT OF ETHANOL EXTRACTS OF GONGRONEMA LATIFOLIUM AND ALTERNANTHERA DENTATE LEAVES IN RATS.
Sylvester Chika Ohadoma*
ABSTRACT
Objective: To comparatively investigate the hepatoprotective effect of ethanol extracts of Gongronema latifolium and Alternanthera dentate leaves in experimental rats. Methods: Two sets (A and B) of four groups comprising five rats each were used. Each of A and B sets had a control group while the other 3 groups were administered different concentrations 100, 200 and 300 mg/kg of ethanol extracts of G. latifolium and A. dentate respectively, once daily for 14 days. The alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB) and bilirubin (BIL) levels were evaluated. Results: All medicaments significantly
(p<0.05) showed reduced ALT, AST, ALP, ALB, BIL and increased TP levels, with G. latifolium exhibiting greater efficacy than A. dentate. Conclusion: The leaves extracts of G. latifolium and A. dentate possess hepatoprotective effect.
Keywords: Gongronema latifolium, Alternanthera dentate, hepatoprotective effect, comparative analysis.
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