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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

ESTIMATION OF TRANEXAMIC ACID IN ITS TABLET AND BULK FORMULATION BY RP-HPLC METHOD

M. S. Teli*, Snehal Shukla and S. S. Sawant

ABSTRACT

Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts its antifibrinolytic effect by blocking lysine-binding sites on plasminogen molecules. This inhibits the interaction of plasminogen and the heavy chain of plasmin with lysine residues on the surface of fibrin. A simple, rapid and specific method for analysis of mefenamic acid in bulk and tablet dosage form by a sensitive high-performance liquid chromatography is described. The tranexamic acid peak was developed on a C8 column to provide optimum resolution with a short time analysis a mobile phase of acetonitrile: water. The limit of quantitation and limit of detection of Tranexamic acid in tablet was 0.059334Î¼g/ml and0.01958Î¼g/ml at 418 nm. The method was linear over the range of 3-9Î¼g/ml with r2 of 0.999667.

Keywords: Tranexamic acid, limit of quantitation, RP-HPLC, High-performance liquid chromatography.

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