Abstract

FORMULATION & DEVELOPMENT PANTOPRAZOLE LOADED MICROSPONGES FOR MANAGEMENT OF GERD

Ankit Agarwal*, Tripti Shukla, Neha Jain, Neeraj Upmanyu, SharadPrakash Pandey, Vinod Dhote

ABSTRACT

The aim of the present research is to develop multiple unit dosage form as microsponge of a drug meant for management of gastroesophageal reflux disease (GERD) using pantoprazole sodium. Microsponge containing pantoprazole sodium as active pharmaceutical ingredient with varying concentration of polymer (Eudragit RS 100), emulsifier (Poly vinyl alcohol) were obtained successfully using Quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape. The physical characterization showed that microsponge
formulation coded by F6 showed a better loading efficiency and production yield. loading efficiency and production yield. The drug release profiles of the pantoprazole microsponge The drug release profiles of the pantoprazole microsponge formulations were found to range from 81.32% to 89.34% from all formulations. Formulation F6 showed 83.62% studied for 6 months. From the various release kinetic models the formulation F6 has Higuchi release pattern followed zero order reaction kinetics (r2= 0.948, 0.965 and 0.983).

Keywords: Gastroesophageal reflux disease, Pantoprazolee, Poly vinyl alcohol, Eudragit RS 100, Quasi-emulsion solvent diffusion, scanning electron microscopy.