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Abstract

INVITRO DISSOLUTION STUDY OF METRONIDAZOLE FILM COATED TABET 400 MG (FLAGYL) IN THE PRESENCE OF DIFFERENT TEA.

*Amber Nawab, Samina Alam and Nousheen Shoukat

ABSTRACT

Background: Experimental research has been conducted in order to have a comparative invitro dissolution profile of metronidazole tablet using variable dissolution medium (green tea, black tea and gastric medium). Objective: The purpose of accomplished work is to obtain a better knowledge regarding the prompt dissolution of metronidazole tablet in a respective dissolution medium in order to attain the most quick, rapid and profound therapeutic effect of the metronidazole tablet. Methodology: The dissolution outline of marketable formulation of metronidazole film coated tablet 400mg available in Karachi (Pakistan) were used for evaluation of brand (flagyl) with different vehicle (green tea, black tea, gastric medium ph 1.2) Simulated gastric conditions have been adopted along with distinct media to find out the maximum and appropriate dissolution of metronidazole in any vehicle among them. Result: The metronidazole 400mg tablet were dissolved reasonably higher in black tea with gastric medium as compare to green tea in gastric medium in 60 minutes. Conclusion: Tablet is the agent to play a major role in curing any ailment. But for performing its action tablet has to pass different parameters for the reason of giving its therapeutic effect. A single tablet lifecycle comprises of ADME i.e. absorption, distribution, metabolism and excretion. And after absorption and distribution and sometimes after metabolism tablet plays its actual role i.e. introducing pharmacological effect. But before starting this cycle tablet must have to dissolve first rapidly, maximally and properly in order to be called as therapeutically active and to increase patient compliance. So the dissolution is the main criteria to be focused in a drug’s life matrix for achieving accurate, intense and quick relief from illness. Therefore, here it has been concluded from the practical approach that black tea faster the beneficial reaction of metronidazole 400mg tablet and start the quick reaction as evaluate to green tea. It would be very benefactor to administer metronidazole along with black tea for prompt therapeutic effect of drug and thus speedily palliate from ailment.

Keywords: Metronidazole film coated tablet, evaluation, dissolution, green tea and black tea.


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