Abstract

A REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEMS

Sayyed Sarfaraz Ali Riyasat Ali*, Pentewar R.S, Gholve S.B, Sugave R.V, Bhosle P.H, Shaikh F.E.

ABSTRACT

The most convenient method of drug delivery System is oral route which is due to patient's compliance, it's reliability, ease of administration and flexibility of formulation. Gastro retentive drug delivery system has lot of advantages and applications which include significance of prolong gastric residence time of drug and improve bioavailability, reduce drug wastage, enhance solubility of those drugs specifically that are poorly soluble in high ph environment. The another important physiology is that gastro retention facilitate local drug delivery to the stomach & proximal small intestine. This technology has novel approach for those drugs which have narrow absorption window in Gastric intestinal tract. Gastro retentive drug delivery system is designs in such a way that it must retain in stomach for prolonged time & release active drug and hence, thereby provide sustainable and long time input of drug to the upper part of Gastric intestinal tract. Enormous amount of attention has been generated towards this novel technology since, from last few decades owing to their potential usefulness to improve solubility & bioavailability thereby targeting site specific release. Ultimately, enhancing their therapeutic outcome. This technique has a innovative approach for those drugs having narrow absorption window in gastric intestinal tract. Owing to it's reliability, we can consider the significant applicability of gastro-retentive drug delivery in future days.

Keywords: Gastro-retentive drug delivery, Solubility, Gastric residence, Bioavailability.