Abstract

THE IMPACT OF METFORMIN ON PSYCHOSOCIAL WELLBEING AFFECTING QUALITY OF LIFE AMONG MALAYSIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Manvikram Singh Gill, Prabhu M*, Radha Prabhu, Nagavalli D And Nina Varghese

ABSTRACT

Background: Polycystic ovary syndrome (PCOS) is proven to cause a reduction in wellbeing and quality of life (QoL). The aim of this study was to monitor the impact of metformin on mental health issues of psychosocial wellbeing affecting the quality of life among Malaysian women with PCOS. Materials and Method: A cross sectional study was carried out at the outpatient clinic of obstetrics and gynecology (OnG) department at Hospital Ampang and Hospital Serdang for 4 months by convenient and purposive sampling where 100 patients were enrolled equally into without metformin group and with metformin group, based on their pharmacotherapy for their PCOS management. Validated instrument for this study consists from combination of Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), Rosenberg’ Self-Esteem Scale (RSES), Liebowitz’ Social Anxiety Scale (LSAS) and SF-36 Quality of Life Scale (SF-36), which was then handed out for comparison between the groups. Results: The independent t-test was conducted and results indicated significant positive differences in the mean score of anxiety, depression, self-esteem, social anxiety and QoL of respondents in with metformin group. The changes in mean score was highest in QoL, showing a higher score of 90.60 (17.60) in with metformin group compared to score of 80.40 (15.45) in without metformin group. Except for self-esteem (p>0.05), significant differences in the anxiety, depression, social anxiety and QoL (p<0.05) are observed in comparison with both groups. The odds ratio was conducted and results indicated that with metformin group QoL is 5.4176 times better than without metformin group QoL. Conclusion The findings revealed that metformin had a positive impact in enhancing mental health issues of psychosocial wellbeing and quality of life among Malaysian women with PCOS.

Keywords: Polycystic Ovarian Syndrome, Metformin, Psychosocial wellbeing, Quality of Life.