WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF NEW SERIES OF SULFAMETHOXAZOLE DERIVATIVES

Monther Faisal Mahdi*, Rafah Fadhil Al-Smaism, Zainb Mohammed Abd Al-Khaliq

ABSTRACT

Sulfamethoxazole belongs to the sulfonamide group of antibiotic. It was chosen to be the representative of this group due to its widespread use and detection frequency in the aquatic environment. Therefore, new series of sulfa drugs, sulfamethoxazole substituted 5-arylidene -4-thiazolidinone, compounds (M3-8) have been designed and synthesized, these compounds expected to have higher antimicrobial than sulfamethoxazole, due to thiazolidinone derivative pharmacophore. The chemical structure of intermediate and final compounds were characterized and confirmed by measuring their melting points, FT-IR spectroscopy, elementalmicroanalysis (CHNS) andHNMR of final compounds. The preliminary study of antimicrobial activity were done on 3 different strains of bacteria and showed that the final compounds (M3-8) have significant activity compared with standard drug (Sulfamethoxazole).

Keywords: Sulfamethoxazole; thiazolidinones; chalcones; heterocycles ; antimicrobial.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More