Photo Gallery

Login

Search

News & Updation

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2018 Issue has been successfully launched on 1 April 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

STUDY OF THE EFFECT OF HORSE CHESTNUT ON DEPRESSION SYMPTOMS INDUCED BY LEAD ACETATE IN RATS

Bassant M.M.Ibrahim*, Abeer A.A.Salama, Dina A.A. Labib, Afaf S.Osman, Reham Sh E. Esmail, Wesam Ismail

ABSTRACT

Depression is a state of low mood and aversion to activity that can affect thoughts, behavior, feelings and sense of well-being. Decreased cerebral levels of the monoamines: serotonin (5-HT), noradrenaline, dopamine (DOPA) are associated with occurrence of depression. Selective serotonin reuptake inhibitors (SSRIs) are used for treatment of depression. Modern medicine recognizes herbalism as a form of alternative medicine. In this study the protective effect of Horse Chestnut on lead acetate induced depression model in rats is tested. In the present study rat groups were classified as follows; the 1st was negative control, the 2nd was positive control where animal model of depression was induced by using lead acetate in a dose of 60mg/kg for four successive weeks, the 3rd,4th and 5th were treated with Fluoxetine 1.8mg/kg, and Horse Chestnut in doses 8.91 and 17.82mg/kg. Pharmacological tests of motor activity by counting number of movements of rats /5 minutes in Grid floor activity cage and pain hypersensitivity by thermal test using Hot Plate apparatus were evaluated. Biochemical tests of cerebral levels of serotonin (5-HT), noradrenaline, dopamine (DOPA), using HPLC, and tests of the antioxidant effect of Horse Chestnut as reduced glutathione level(R-GSH) and amount of lipid peroxides (MDA) were determined in cerebral homogenates. Histopathology examination of cerebral hemispheres was performed. Lead acetate in that study produced significant deterioration in all tests and biochemical parameters while Fluoxetine and Horse Chestnut had a protective effect on rat brains as evident in all tests and biochemical parameters.

Keywords: Depression; Horse Chestnut; Lead acetate; Behaviour; Serotonin.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More