Abstract

DICLOFENAC LOADED CROSSLINKED SODIUM ALGINATE AND GELLAN GUM MICROSPHERES: DEVELOPMENT AND IN VITRO RELEASE PROFILE

Akash Roy, Sudipta Das*, Arnab Samanta

ABSTRACT

Diclofenac loaded microspheres were prepared using sodium alginate and gellan gum and were cross-linked by maleic anhydride, aluminium chloride or calcium. DSC study shows there was no interaction between drug and excipients. The resulting microspheres were evaluated for surface morphology analysis by SEM, entrapment efficiency, percentage yield, particle size analysis, in-vitro release study and swelling index. Entrapment was fair in all the formulations while the maximum entrapment (98.1%) was recorded in formulation cross-linked by aluminium chloride and their average particle size were 140 to 150 m. From this experiment, it is observed that the formulation with cross-linked by aluminium chloride is the better formulation among others due to good release profile (51.56% over 6 hr), entrapment efficiency and surface morphology behaviour.

Keywords: Microspheres, Diclofenac, Gellan gum.