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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

SYNTHESIS AND IN VITRO ANTI-BREAST CANCER EVALUATION OF SOME NOVEL 1, 3-THIAZINES AND THIAZOLONE DERIVATIVES INCORPORATING PYRAZOLE MOIETY

Abdou O. Abdelhamid*, Ahmad S. Shawali, Sobhi M. Gomha and Waleed A.M.A. El-Enany

ABSTRACT

New series of novel functionalized 1,3-thiazines containing pyrazole moiety was synthesized using 4-acetylpyrazole as a precursor. The structures of the compounds prepared were confirmed by both spectral and elemental analyses and by alternate synthesis. The mechanisms of the reactions studied were also discussed. The newly synthesized compounds have been evaluated for their antitumor activity against human breast carcinoma (MCF-7) cell lines and the results showed good inhibition effects comparable to Doxorubicin, used as a standard.

Keywords: Pyrazoles, Thiosemicarbazones, 1,3-Thiazines, Thiazolone, Anticancer activity.


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