Abstract

PROTECTIVE ROLE OF POLYBION AGAINST RADIATION AND CADMIUM INDUCED HAEMATOLOGICAL CHANGES IN THE SWISS ALBINO MICE

Damodar Kumar Joiya and R. K. Purohit*

ABSTRACT

The present study was aimed to evaluate the protective effect of polybion against radiation and cadmium induced haematological changes in the Swiss albino mice. The five animals from each experimental group were sacrificed by cervical dislocation at post-treatment interval of 1,2,4,7,14 and 28 days. After sacrificing the animals, the blood was collected by cardiac puncture in heparinized tubes for various haematological studies. The values of RBC, WBC, Haemoglobin, PCV and MCV were found to decrease in all the groups as compared to normal groups, but the decrease in these values was lesser in polybion treated groups. On the other hand the value of MCH and MCHC increased in all the groups at various intervals. After combined treatment of radiation and cadmium chloride simultaneously synergistic effects were observed. The polybion treated animal exhibited less severe damage as compared to non- drug treated animals at all the corresponding intervals. An early and fast recovery was also noticed in polybion pretreated animals. Thus, it appears that polybion is potent to enough to check cadmium and radiation induced haematological changes in Swiss albino mice.

Keywords: Polybion, Anti oxidants, Heavy metal, Blood, Radioprotection.