Abstract

IMPACT OF HERBAL SYNERGY ON ANTIOXIDANT EFFICACY OF A NOVEL FORMULATION

Geeta Watal* and Amrita Kumari Srivastava

ABSTRACT

Synergistic effect of herbs in a formulation leads to the development of combination therapy. Since, medicinal plants are a well known source of several natural antioxidants in the form of diet, therefore, two medicinally important edible plants viz. Murraya Koeingii and Sesamum indicum, known for their antioxidant efficacy were selected for the present study. Herbal formulation (HF) was prepared by the combination of standardized aqueous extracts of Murraya koeingii (MK) leaves and Sesamum indicum (SI) black seeds. The study was undertaken to explore the impact of synergy on antioxidant efficacy of individual herbs in a herbal formulation. Various assays used for evaluating antioxidant efficacy were total phenolics, total flavonoids, total antioxidant power (FRAP), Reducing power and Metal chelating activity. Free radical scavenging activity of herbal formulation as well as of its individual herbs was also assessed for various radicals viz. DPPH, ABTS, Nitric oxide, Hydroxyl and Superoxide radicals. The data reveals that the antioxidant efficacy of the herbal formulation significantly enhances due to the synergistic effect of both the herbs, Murraya Koeingii and Sesamum indicum. Thus, this formulation of MK leaves and SI seeds could be explored not only as an antioxidant therapeutic agent but also as an agent for managing diabetic complications viz. Oxidative Stress associate with hyperglycemia.

Keywords: Herbal Formulation, Murraya Koeingii and Sesamum indicum.