Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF CEFEXIME TABLET BY USING BIOPOLYMER AS A RELEASE MODIFIER FROM DRIED SEED OF JACKFRUIT (ARTOCARPUS HETEROPHYLLUS)

Belwal Vijay*, Arya Vikram, Kumar Alok

ABSTRACT

In the recent years the research in biomaterial science becomes a core area for the formulation scientist to develop a safe and effective drug delivery system. Recently biopolymer was used as material for conventional as well as novel dosage form development. biopolymer have advantage that they chemicaly inert, nontoxic, cost effective, ecofriendly, biodegerdable ,biocompatible and esaily accepted by reglulatory authority as compared to synthetic conterpart.The objective of present study was to develop sustained release tablets of cefexime by using novel isolated biopolymer as a release modifier ,obtained from dried seed of jackfruit (Artocarpus heterophyllus).The biopolymer was extracted by non solvent addition method and characterized their physiochemical ,phytochemical and micromeritic property. The sustained release tablet of cefexime were prepared through wet granulation methods by using different ratios (1:1,1:1.5,1:2,1:2.5 and 1:3) of drug and biopolymer. Further the tablet were evaluated for its weight variation, friability, hardness, drug content and in vitro dissolution study. The result obtained from the above study was found to under limit as pharmacopoeial standard. So the research from the study shows that the biomaterial obtained from the jackfruit (Artocarpus heterophyllus) serves as a better release modifier in the development of sustained release tablet . So jack fruit biopolymer can be used as a better alternative excipient for the development novel drug delivery system.

Keywords: Biopolymer, sustained release tablet, Artocarpus heterophyllus.