WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DESIGN AND OPTIMIZATION OF AMBROXOL HCL MICROPARTICLES FOR BITTER TASTE MASKING

*Abhijeet Y. Patil1, Pravin K. Bhoyar2, Jagdish R. Baheti3, Satish M. Kardel3, Chandrakant T. Karanjekar1, Dhanashri B. Nagulwar4

1School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.
2Siddhivinayak College of Pharmacy,Warora, Dist-Chandrapur, Maharashtra, India.
3Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India.
4Department of Pharmaceutics, Sharad Pawar College of Pharmacy, Dist: Nagpur, Maharashtra, India.

ABSTRACT

In the present work, bitter taste of Ambroxol hydrochloride is masked by preparing microparticles of drug with certain hydrophilic polymers such as Hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP) by using spray drying technique. Microparticles of Ambroxol hydrochloride and polymers were prepared in ratio of 1: 3: 3 (0.1gm drug, 0.3gm HPMC and 0.3gm PVP respectively) by spray drying technique. Morphology and characterization of the prepared Ambroxol hydrochloride microparticles was studied. The percentage yield of microparticles was found to be 62%. The encapsulation efficiency was found to be 67.30%. %. The in vitro drug release was found to be 61.65% and 72.86% in 0.1N HCL and pH 6.8 phosphate buffer solutions.

Keywords: Ambroxol, Hydroxy propyl methylcellulose (HPMC), Polyvinyl pyrrolidone (PVP), Spray drying, Taste masking.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More