Abstract

BULL’S EYE (IN-LAY) TABLET: FIXED DOSE COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE BY STEAM GRANULATION TECHNIQUE

Dr. T. V. Rao* and N. Bhadramma

ABSTRACT

The main objective of the investigation was to design and development of the fixed dose combination of Glipizide and Metformin Hydrochloride in-lay tablets prepared by steam granulation technique. The prepared granules were evaluated for angle of repose, bulk density, carr‟s index and Hausner‟s ratio, results revealed that preparation of granules were found to be good flow properties and the tablets were evaluated for hardness, friability, thickness, % drug content and in vitro release studies. In-lay tablet comprises of glipizide immediate release layer formulated with neem gum as disintegrating agent and metformin hydrochloride for sustained release formulated with HPMC K4M and gums such as xanthum gum and guar gum in which SR layer surrounded by glipizide immediate release granules. The drug-excipient compatibility studies were conducted by FT-IR studies. The mechanism of drug release from glipizide IR layer follows first order kinetics and zero order kinetic observed for metformin hydrochloride SR layer and the stability studies were performed as per ICH guide lines for formulated F9 and results obtained found to be stable.

Keywords: Metformin hydrochloride, Glipizide, Guar gum, Xanthum gum.