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Abstract

ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF PITAVASTATIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW

B.Thapaswini*, T.Rammohan Reddy, A.Ajitha, V.Uma Maheswara Rao

ABSTRACT

Pitavastatin Calcium is a member of the medication class of statins. The IUPAC name (3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3, 5-dihydroxyhept-6-enoic acid with molecular formula C25H24FNO4 (421.461).Pitavastatin completely inhibits HMG CoA reductase, the rate-determining enzyme in hepatic cholesterol synthesis. Consequently, LDL-C receptors in the liver are increased, thereby increasing the removal of LDL-C from the blood. The primary route of metabolism of pitavastatin was hepatic glucuronidation with minimal metabolism by cytochrome P450 2C9 (CYP 2C9) and CYP 2C8.It is being marketedunder license in South Korea and in India. It is likely thatpitavastatin will be approved for use in hypercholesterolaemia. Literature survey reveals that meloxicam is estimated individually by RP-HPLC, ,determination of impurity and assay by RP-HPLC, Stability indicating UPLC and HPLC, HPTLC and stablity indicating HPTLC,LC-MS/MS by using solid phase extraction Technique.

Keywords: Pitavastatin, RP-HPLC,UPLC,HPTLC,LC-MS/MS.


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