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Abstract

ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF VALSARTAN IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW

P.Sripriya*, G.Naga Sowjanya, A.Ajitha, V.Uma Maheswara Rao

ABSTRACT

Valsartan is 3-methyll-2-[pentanoyl-[[4-[2-(2H-tetrazoyl-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid with empirical formula C24H29N5O3. Its molecular weight is 435.519g/mol. Valsartan is an orally active Angiotensin II receptor type 1 antagonist which causes reduction in blood pressure and is used in treatment of hypertension. It was first developed by Novartis and has a wide market in the developed and the developing countries. It is also available in combination with other antihypertensive drugs. It is a lipophilic drug and possesses moderate onset of action than other drugs of the same category. The drug is a very good target for the generic industries. Literature survey reveals that Valsartan is estimated individually by uv spectrometry, PH Dependent spectroscopic Method, RP-HPLC, HPLC/MS/MS and stability indicating RP-HPLC and stability indicating UPLC, Solid phase extraction coupled to electron spray tandem mass spectroscopy.

Keywords: Valsartan, RP-HPLC,UPLC,UV,HPLC-MS/MS,SPE ESTMS


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