Abstract

“CORRELATION BETWEEN SERUM URIC ACID LEVEL AND DIABETIC PERIPHERAL NEUROPATHY: A CASE CONTROL STUDY”

Kishalay Jana*

ABSTRACT

Background: It is known to all that uric acid is a key reason for the progression of retinopathy and nephropathy in diabetic patients. This study focuses to evaluate the of serum uric acid levels in patients with and without diabetic peripheral neuropathy (DPN). Methods: Sixty patients with DPN (experimental group) and 60 patients without DPN (control group) were selected and matched with regard to age, sex, body mass index (BMI) and the duration of their different diseases were entered into the study. DPN was diagnosed by nerve conduction studies of lower limbs nerves i. e. sural, tibial and peroneal. We also collect the data of serum uric acid, creatinine and HbA1c level in two separate group. Results: Results shows that the demographic characteristics of the two separate group were same but the history of diabetic foot ulcer was higher in experimental group (p<0.05) when compare to control group. The patients mean age of the experimental group was 55.6±5.3 years and in the control group was 56.8±6.1 years (p=0.401). The serum uric acid level in experimental group was 7.6±0.76 (mg/dl) and in case of control group it was 4.8±0.82 mg/dl (p=0.048). Serum creatinine and Glycated hemoglobin (HbA1C) level also high in case of experimental group than control group of patients. Conclusion: The results indicated that higher level of serum uric acid level is form in diabetic patients with diabetic neuropathy. More research is required to study the role of serum uric acid for the progression of DPN.

Keywords: Diabetes mellitus, neuropathy, uric acid.