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Abstract

EVALUATION OF QUALITY CONTROL PARAMETERS ON VARIOUS BRANDS OF PARACETAMOL TABLET FORMULATION

*Neha Mathur, Ravi Kumar, Kankshi Tiwari, Supriya Singh and Nikhat Fatima.

ABSTRACT

Paracetamol (Acetaminophen) is a widely used OTC medicine available as compressed tablets. It is marketed and manufactured by a number of pharmaceutical companies and is widely used as an analgesic, antipyretic medicine. In the present study we selected three brands of Paracetamol tablets (Brand X, Brand Y and Brand Z) which are easily available and commonly used for analgesic and antipyretic action. Further, the purpose of the present study was to perform the various quality control tests of the compressed tablets like, weight variation, hardness, friability, disintegration and dissolution as per the official monographs[12,13] B.P, U.S.P and evaluate these three different brands. As a result was this study we found that all the three brands met the specifications laid down in the official monographs. They differ only slightly in terms of various quality control parameters, brand Z disintegrated faster, had faster dissolution rate and so its % drug release was more than the other two brands at the same time.

Keywords: Paracetamol, Quality control tests, weight variation, hardness, friability, dissolution, disintegration time.


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