Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF FRUSEMIDE USING NATURAL HYDROPHILIC POLYMERS

*Vishnumurthy Vummaneni, Dheeraj Nagpal

ABSTRACT

Frusemide sustained-release matrix tablets were formulated using natural hydrophilic polymers like Guargum, Pectin, Gum Tragacanth and Xanthan gum. The formulated tablets were evaluated for physical characteristics like weight variation, thickness, hardness, friability and drug content. The results of the physical characteristics of all formulations were with in the acceptable limits. In vitro drug release study was performed using PBS pH 7.2 for a period of 16 hours. Tablets formulated with Guargum exhibited higher swelling index than that of tablets with other natural polymers used. The in vitro release data was well fit into Peppas model of release kinetics. Better controlled drug release was obtained with matrix tablets made of Guargum than that of tablets with other polymers.

Keywords: Sustained release, Frusemide, Guargum, Gum Tragacanth, Pectin & Xanthan gum.