Abstract

DIFFERENT ANALYTICAL TECHNIQUES FOR QUANTITATIVE ANALYSIS OF ATORVASTATIN CALCIUM IN BULK AND PHARMACEUTICAL DOSAGE FORMS

M.Sumanth*, S.Sirishchandra, Dr.T.RammohanReddy, A.Ajitha, and V.Umamaheshwararao

ABSTRACT

Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol. Primary uses of atorvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease. Since many years, varied analytical methods were developed in dosage forms and in order to estimate their desired pharmacological action. A few UV spectrometric methods have been reported to estimate the atorvastatin in bulk formulations. Ultimately, different Fluorimetry, visible spectrometric and HPLC methods explained the importance of the methods while estimation atorvastatin in various stability indicating studies as well as in routine drug analysis. This review provides clear and short notes on the various analytical techniques employed for determination of atorvastatin in both bulk and pharmaceutical dosage form.

Keywords: Atorvastatin, dyslipidemia, Fluorimetry, visible spectrometry and HPLC.