Abstract

A REVIEW ON MUCOADHESIVE BUCCAL TABLETS PREPARED USING NATURAL AND SYNTHETIC POLYMERS

Ankaj Kaundal*, Pravin Kumar and Archana Chaudhary

ABSTRACT

Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or indirectly. In recent years there has been an important development in different dosage forms for existing and newly designed drugs and natural products, and semi-synthetic as well as synthetic excipients often need to be used for a variety of purposes. Gums and mucilages are widely used natural materials for conventional and novel dosage forms. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. Buccal transmucosal delivery helps to bypass first- pass metabolism by allowing direct access to the systemic circulation through the internal jugular vein. This article briefly describes isolation of mucilage, the basis, requirements, the standards of an ideal mucoadhesive buccal drug delivery advantages, limitations, mechanism of mucoadhesion, structure of buccal mucosa, theories of mucoadhesion, investigated buccal tablets containing natural polymer, evaluation parameters, commercially available buccal adhesive tablets etc.

Keywords: Natural polymers, Mucoadhesion, Theories, Factors affecting mucoadhesion, Oral mucosa, evaluation, mucoadhesive tablets, buccal drug delivery.