Abstract

EFFECT OF CAESALPINIA SAPPAN LINN CHLOROFORM EXTRACT ON ALLOXAN INDUCED DIABETES MELLITUS IN RATS

Manoj Khanna Nalla, Madhan Mohan Elsani, Krishna Mohan Chinnala*

ABSTRACT

Diabetes mellitus is a metabolic disorder characterized by a loss of glucose homeostasis caused by pancreatic β-cell destruction or because of insulin resistance. Complications in some of these organs can lead to death. Management of diabetes mellitus is a global concern and successful treatment is very essential for preventing or at least delaying the onset of long-term complications of the disorder. It is believed that the traditional medicines used for the treatment of diabetes mellitus to attenuate the progression of complications of the disease. The search for the effective herbal drugs for the treatment of diabetes based on ethno medical clues still continues and in the long run has yielded us invaluable herbal remedies. To prove the ethno medical use of such folkloric traditional medicines, we have selected such ethno botanically important Caesalpinia sappan Linn, a plant used in the traditional systems of medicine in India for various uses. Chloroform extract of Caesalpinia sappan Linn. (CECS) was used at two dose levels 200mg/kg and 400mg/kg body weight and administered orally for 21 days to Alloxan induced diabetic rats. They significantly (p<0.001) reduced the blood glucose, total cholesterol and triglyceride levels and regulation in serum total proteins levels when compared with the standard Glibenclamide 10 mg/kg body weight.

Keywords: Caesalpinia sappan Linn., Diabetes Mellitus, Alloxan, Glibenclamide.