Abstract

IMPORTANCE OF BIOCHEMICAL MARKERS - ADA AND CRP IN THE BODY FLUIDS FOR THE DIAGNOSIS OF TB AND THEIR CORRELATION IN THE TUBERCULOSIS PATIENT.

Dr. Suman Rao Vihari*, Shainda Laeeq and Istafa Husain Khan

ABSTRACT

Tuberculosis (TB) has been a major global public health problem. Tuberculosis is the commonest opportunistic infection among people living with HIV and in several instances HIV and TB co-exist. Tuberculosis (TB) is a major cause of pleural effusion, which in TB usually has lymphocytic and exudative characteristics. Tuberculosis produces a spectrum of histopathogical reaction in the bone marrow in Patients with poor nutritional status. They range from normal marrow hyperplasia and necrosis of the marrow. There is great excitement in the tuberculosis (TB) scientific community over the introduction of new tools into TB control activities. The development of new tools is an important component of the Global Plan to Stop TB and the World Health Organization’s new global Stop TB Strategy. TB is no longer the scourge it once was, but it remains an important cause of morbidity and mortality worldwide. Tuberculous effusion is usually diagnosed by pleural biopsy as bacteriological examination of pleural fluid, sputum and laryngeal swab specimens is of limited value because of the low diagnostic yields (9-32%) with these methods. In this research we have found two biochemical markers- ADA and CRP which are important in the diagnosis of TB. Adenosine deaminase (ADA) test can be used for early TB detection where TB is endemic or other diagnostic means are expensive in adult population. Adenosine deaminase analysis is a simple and inexpensive colorimetric test that can be performed on serum and body fluids. Use of CRP as a marker for detection helps us not only in diagnosis but also helps us to evaluate progression & effectiveness of drugs used to cure it. The test is under the common men pocket.

Keywords: ADA, CRP, AFB, purine, peritoneal, pericardial.